https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Index ${session.getAttribute("locale")} 5 https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:54321 Wed 28 Feb 2024 15:14:53 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:56049 Wed 24 Jul 2024 11:11:21 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:21992 Bacillus species were identified compared with healthy controls. PCR analyses revealed increased rates of detection of potentially pathogenic bacteria with Haemophilus influenzae detection associated with higher sputum levels of NE and IL-1β, while Streptococcus pneumoniae was more common in male ex-smokers with emphysema and a deficit in diffusion capacity. Conclusion: Non-pathogenic and pathogenic bacteria were altered in the sputum of patients with COPD. These observations highlight the potential to identify treatment and management strategies that both target specific bacterial pathogens and restore the microbial balance, which may lead to reductions in inflammation and subsequent improvements in lung health.]]> Wed 17 Nov 2021 16:31:05 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:48013 Wed 15 Feb 2023 09:38:01 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:12228 Wed 11 Apr 2018 17:11:41 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:21097 Wed 11 Apr 2018 16:34:49 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:11977 Wed 11 Apr 2018 15:41:14 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:15803 Wed 11 Apr 2018 14:28:31 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:11515 Wed 11 Apr 2018 14:24:47 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:11976 Wed 11 Apr 2018 14:10:49 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:6037 Wed 11 Apr 2018 13:55:56 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:29281 Wed 11 Apr 2018 12:14:06 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:12010 Wed 11 Apr 2018 10:08:15 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:16818 Wed 11 Apr 2018 09:59:45 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:23516 Wed 10 Nov 2021 15:04:33 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:41488 Wed 10 Aug 2022 12:25:35 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:41790 Wed 07 Feb 2024 18:05:12 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:50197 Wed 06 Mar 2024 14:42:35 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:37008 Wed 05 Aug 2020 14:09:13 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:33818 Wed 04 Sep 2019 10:04:46 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:52185 Wed 04 Oct 2023 11:03:56 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:37098 Tue 18 Aug 2020 09:48:42 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:41979 Tue 16 Aug 2022 15:48:32 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:30266 Stenotrophomonas (MTS-2) followed by Citrobacter (MTS-3) and Pseudomonas (MTS-1) were furthermost effective in the degradation of HMW PAHs either as individual or in the presence of co-substrate (LMW PAHs). MTS-1, 2 and 3 (co)degraded model LMW PAHs, Phe (100% of 150 mg L^-1) and HMW PAHs Pyr (100% of 150 mg L^-1) or BaP (90-100% of 50 mg L^-1) in 3, 12-15 and 30 days, respectively and recorded the least half-life time (t^1/2) and highest biodegradation rate constants (k). One of the significant findings is the diazotrophic P-solubilization ability, acid and alkali tolerance (optimum pH=5.0-8.0) of the HMW PAHs degrading Pseudomonas strain MTS-1. Stenotrophomonas (MTS-2) was also found to be superior as it could solubilize P and tolerate acidic condition (optimum pH=5.0-7.5) during HMW PAHs degradation. Further, our study is the first evidence of diazotrophic P solubilization potential of Agrobacterium (MTS-4) and P-solubilizing capacity of Citrobacter (MTS-3) during bioremediation. Thus, the results of this study demonstrate the promising use of the newly identified PAH degraders, notably MTS-1, 2 and 3 either as individuals or as consortia as an excellent candidate in the bioremediation or phytoremediation of PAHs contaminated soils.]]> Tue 10 Sep 2024 12:47:27 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:49403 Thu 22 Feb 2024 11:32:12 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:34211 Thu 09 Dec 2021 11:02:18 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:8199 Sat 24 Mar 2018 08:36:19 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:1282 Sat 24 Mar 2018 08:32:29 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:1173 Sat 24 Mar 2018 08:28:27 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:2479 Sat 24 Mar 2018 08:27:44 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:1783 Sat 24 Mar 2018 08:27:33 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:10440 106 cfu/mL) was cultured from the sputum of 17 (15%) subjects with stable asthma and was associated with higher total cell counts, proportion and number of neutrophils, sputum IL-8 and 8-isoprostane concentrations. The role of bacteria in potentiating neutrophilic asthma warrants further investigation. Therapies such as antibiotic and antioxidant treatment may be most effective in this sub-group of patients.]]> Sat 24 Mar 2018 08:13:16 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:11382 Sat 24 Mar 2018 08:11:51 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:20055 70/σ^A for the development of lead molecules exhibiting a novel mechanism of antibacterial activity. Several classes of structurally related bis-indole inhibitors of bacterial transcription initiation complex formation were synthesized and their antimicrobial activities were evaluated. Condensation of indole-7- and indole-2-carbohydrazides with 7- and 2-trichloroacetylindoles or indole-7- and indole-2-glyoxyloyl chlorides resulted in the successful synthesis of 7,7′-, 2,2′-, 2,7′- and 3,2′-linked bis-indole derivatives with –CO–NH–NH–CO– and –CO–CO–NH–NH–CO– linkers. Indole-7-glyoxyloyl chlorides were reacted with hydrazine hydrate in different ratios to afford respective –CO–CO–NH–NH–CO–CO– bis-indole or hydrazide derivatives. The resulting compounds were found to be active against the β′-CHσ⁷⁰/σ^A_2.2 interaction in ELISA assays and inhibited the growth of both Gram-positive and Gram-negative bacteria. Structure–activity relationship (SAR) studies were performed in order to identify the structural features of the synthesized inhibitors required for biological activity.]]> Sat 24 Mar 2018 08:00:13 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:20277 Sat 24 Mar 2018 07:59:53 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:20889 Sat 24 Mar 2018 07:57:55 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:21109 Helicobacter pylori flourish despite the hostile environment. Whilst H. pylori is the most studied bacteria in this region with a defined role in inflammation and neoplasia, it is apparent that other bacteria may contribute to UGI disease. Aim: To review current knowledge of bacteria inhabiting the oesophagus, stomach and duodenum. Methods: Published studies on the upper gastrointestinal microbiome (extracted from PubMed during the last 20 years). Results: The stomach is a hostile environment for bacteria; however, recent studies categorising the microbiota have shown surprising results. Helicobacter pylori has been intensively studied since 1984 and recent sequencing analysis of other gastric microbiota shows that H. pylori is not alone. Composition can be influenced by acid suppression, gastritis and abundance of H. pylori. Eradication of H. pylori, whilst decreasing gastric cancer is associated with an increase in asthma, reflux and obesity. A future approach may be to selectively eradicate bacteria which predispose to inflammation and cancer as opposed to a comprehensive knockout policy. In the oesophagus, viridans streptococci are the most common bacteria influenced by both oral and gastric bacteria. Oesophagitis and Barrett's oesophagus are characterised by a significant decrease in Gram-positive bacteria and an increase in Gram-negative bacteria. An inverse association of H. pylori and oesophageal adenocarcinoma is described. The duodenal microbiome has been shown to influence small intestinal bacterial overgrowth, irritable bowel syndrome and coeliac disease. The numbers of bacteria recoverable by culture are variable in the stomach mucosa and gastric juice, typically 10²-10⁴ colony-forming units (CFU)/g or mL and in the oesophagus, up to 10⁴ bacteria per mm² mucosal surface. In the small bowel, in health, 10³ CFU/mL are normal. Conclusion: This review highlights current knowledge of upper gastrointestinal bacteria and associations with disease.]]> Sat 24 Mar 2018 07:54:02 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:5622 Sat 24 Mar 2018 07:49:20 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:6616 Sat 24 Mar 2018 07:46:22 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:6633 Sat 24 Mar 2018 07:46:21 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:5034 Sat 24 Mar 2018 07:45:39 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:5381 Sat 24 Mar 2018 07:43:55 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:29829 Sat 24 Mar 2018 07:40:53 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:26774 13C values range between ca -6⁰/₀₀ and +4⁰/₀₀, with the most 13C-depleted values in dolomites of the distal alluvial plain and flood basin, and the most ¹³C-enriched in dolomites of the tidal flat and lagoon. Uniform δ¹⁸O values ranging between 0⁰/₀₀ and +3⁰/₀₀ were found in all sedimentary facies. It is hypothesized that the primary dolomite with mosaic microstructure nucleated on extracellular polymeric substances secreted by sulphate reducing bacteria. A multi-step process involving sabkha and reflux dolomitization led to partial replacement and overgrowth of the primary dolomite, but replacement and overgrowth were facies-dependent. Dolomites of the landward, clay-rich portion of the sedimentary system were only moderately overgrown during late dolomitization steps, and partly retain an isotopic signature consistent with bacterial sulphate reduction with δ¹³C as low as -6⁰/₀₀. In contrast, dolomites of the marine, clay-free part of the system were probably transformed through sabkha and reflux diagenetic processes into calcian varieties, and exhibit δ¹³C values of ca +3⁰/₀₀. Major shifts of δ¹³C values strictly follow the lateral migration of facies and thus mark transgressions and regressions.]]> Sat 24 Mar 2018 07:24:46 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:24505 Sat 24 Mar 2018 07:13:10 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:51964 2 μm) of microbial DMSP lyase activity. Seasonal increases of the bacterial DMSP biosynthesis gene (dsyB) and the bacterial DMS oxidation gene (tmm) occurred during the spring-summer and coincided with peaks in DMSP and DMSO concentration, respectively. These findings, along with significant positive relationships between dsyB gene abundance and DMSP, and tmm gene abundance with DMSO, reinforce the significant role planktonic bacteria play in producing DMSP and DMSO in ocean surface waters. Our results highlight the highly dynamic nature and myriad of microbial interactions that govern sulfur cycling in coastal shelf waters and further underpin the importance of microbial ecology in mediating important marine biogeochemical processes.]]> Mon 25 Sep 2023 08:45:56 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:44905 Mon 24 Oct 2022 16:10:33 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:47590 Mon 23 Jan 2023 14:49:25 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42308 Camp^-/-) and exogenous cathelicidin prevented ICS-mediated expansion of streptococci within the microbiota and improved bacterial clearance. Suppression of pulmonary immunity by ICS was mediated by augmentation of the protease cathepsin D. Collectively, these data suggest a central role for cathepsin D/cathelicidin in the suppression of antibacterial host defense by ICS in COPD. Therapeutic restoration of cathelicidin to boost antibacterial immunity and beneficially modulate the lung microbiota might be an effective strategy in COPD.]]> Mon 22 Aug 2022 10:35:15 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:46404 P = .002 vs controls), but not alcohol use. Infection with Helicobacter pylori was not associated with Menetrier’s disease (2.6% of patients vs 4.0% of controls; P = 1.00). There was no significant difference between patients with Menetrier’s disease vs controls in proportions with inflammatory bowel disease. Gastric cancer developed in 8.9% of patients with Menetrier’s disease by 10 years after the Menetrier’s disease diagnosis vs 3.7% of controls over the same time period (P = .09). Of patients with Menetrier’s disease, 72.7% and 65.0% survived for 5 and 10 years, respectively, compared with 100% of controls (P < .0001 for both time periods). Conclusions: In a case–control study of 76 patients with Menetrier’s disease, we found this rare disorder to be associated with increased mortality. Patients with Menetrier’s disease therefore should be followed up with surveillance endoscopy.]]> Mon 21 Nov 2022 15:15:45 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:33740 Mon 17 Dec 2018 08:16:03 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:53775 Mon 15 Jan 2024 10:09:33 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:4209 Mon 09 Sep 2024 13:48:24 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:40845 Mon 08 Aug 2022 15:39:55 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42819 Mon 05 Sep 2022 11:21:26 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:41291 96%) (environmentally responsive community) of the species-specific microbiome were in fact not found in association with the majority of individuals of the species. Only 0.1% (~21 phylotypes) of the species-specific microbiome of each species was shared among all individuals of the species (core microbiome), equating to ~3.4% of the resident microbiome. We found taxonomic redundancy and consistent patterns of composition, structure, and taxonomic breadth across individual microbiomes from the three coral species. Our results demonstrate that the coral microbiome is structured at the individual level. Importance: We propose that the coral holobiont should be conceptualized as a diverse transient microbial community that is responsive to the surrounding environment and encompasses a simple, redundant, resident microbiome and a small conserved core microbiome. Most importantly, we show that the coral microbiome is comparable to the microbiomes of other organisms studied thus far. Accurately characterizing the coral-microbe interactions provides an important baseline from which the functional roles and the functional niches within which microbes reside can be deciphered.]]> Mon 01 Aug 2022 12:02:22 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:45456 Fri 28 Oct 2022 14:23:02 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:25582 E. coli and 1.67 for total coliforms, and the highest concentration of indicator bacteria in treated water samples were found during the monsoon season. Analysis of variance revealed significant differences in the microbial load of indicator organisms (coliforms and E. coli) between seasons, storage time since treatment (TST), and samples with and without chlorine residuals. Findings indicate that the bacteriological quality of drinking water treated in the home is determined by a complex interaction of environmental and sociological conditions. Moreover, while the effect of disinfection was independent of season, the impact of storage TST on water quality was found to be seasonally dependent.]]> Fri 22 Apr 2022 10:21:56 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:49376 Fri 12 May 2023 14:13:07 AEST ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:48161 Fri 10 Mar 2023 13:58:47 AEDT ]]> https://novaprd-lb.newcastle.edu.au/vital/access/ /manager/Repository/uon:42982 Fri 09 Sep 2022 13:56:36 AEST ]]>